Recent Publications

Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia

Published on: 5th December 2017

Published in 2017

Pub Med ID: 29187730

Joey Ward, Rona J. Strawbridge, Mark E. S. Bailey, Nicholas Graham, Amy Ferguson, Donald M. Lyall, Breda Cullen, Laura M. Pidgeon, Jonathan Cavanagh, Daniel F. Mackay, Jill P. Pell, Michael O’Donovan, Valentina Escott-Price & Daniel J. Smith


Mood instability is a core clinical feature of affective and psychotic disorders. In keeping with the Research Domain Criteria approach, it may be a useful construct for identifying biology that cuts across psychiatric categories. We aimed to investigate the biological validity of a simple measure of mood instability and evaluate its genetic relationship with several psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, attention deficit hyperactivity disorder (ADHD), anxiety disorder and post-traumatic stress disorder (PTSD).

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