Published on: 5th December 2017
Published in 2017
Pub Med ID: 29187730
Joey Ward, Rona J. Strawbridge, Mark E. S. Bailey, Nicholas Graham, Amy Ferguson, Donald M. Lyall, Breda Cullen, Laura M. Pidgeon, Jonathan Cavanagh, Daniel F. Mackay, Jill P. Pell, Michael O’Donovan, Valentina Escott-Price & Daniel J. Smith
Mood instability is a core clinical feature of affective and psychotic disorders. In keeping with the Research Domain Criteria approach, it may be a useful construct for identifying biology that cuts across psychiatric categories. We aimed to investigate the biological validity of a simple measure of mood instability and evaluate its genetic relationship with several psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, attention deficit hyperactivity disorder (ADHD), anxiety disorder and post-traumatic stress disorder (PTSD).