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Discover the Best Nootropics for Energy, Focus, and Motivation [2023]

Discover the Best Nootropics for Energy, Focus, and Motivation [2023]

By Kire Stojkovski M.D
Editor Jonathan Hoarau Published 08 August 2023
Time to read 32 min

Maintaining focus, energy, and motivation is often the key to success in our fast-paced world. In response to the increasing demand for cognitive enhancement, the market has seen a surge in dietary supplements known as nootropics. These brain-boosting supplements aim to augment memory, creativity, motivation, and other aspects of cognitive function.

While some nootropics are pharmaceuticals requiring a prescription, many are available over the counter as dietary supplements. This article enlightens you on the best nootropics for energy, motivation, and mental clarity. We will also explore the available nootropics, their potential benefits, risks, and side effects. Let’s dive in!

Best Nootropics for Energy – Quick Overview

  • NooCube – Best Nootropics for Energy That Is Caffeine-Free
  • Brain Pill – Best Nootropics for Energy and Fighting Brain Fog and Anxiety
  • FOCL Day – Best Nootropics for Motivation and Natural Energy
  • Elm & Rye – Best Nootropics for Energy and Mental Focus
  • BetterBrand – Best Nootropics for Energy for Various Dietary Needs
  • MindLab Pro – Best Nootropics for Energy and Productivity

What Are Nootropics?

Nootropics, colloquially known as ‘smart drugs’, ‘brain boosters’, or ‘cognitive enhancers‘, are a class of substances – be it drugs, supplements, or other consumables – believed to enhance cognitive function. 

The term ‘nootropic’ is derived from the Greek words ‘nous’, meaning ‘mind’, and ‘tropos’, meaning ‘turn’. Thus, nootropics are substances that ‘turn the mind’, improving mental processes. [1]

Nootropics are categorized into two primary types: natural and synthetic nootropics.

  1. Natural Nootropics: These supplements derived from nature, often from plant extracts, are believed to enhance cognitive function. They are not regulated by the FDA but are used widely due to their minimal side effects.
  2. Synthetic Nootropics: These are pharmaceutical drugs that have a powerful effect on brain function. The FDA regulates them and usually requires a prescription.

Now that we understand what nootropics are let’s delve into some of the best nootropics for energy and motivation.

Understanding Your Energy, Focus and Motivation Needs

Before diving into the best nootropics for energy, focus, and motivation, it’s crucial to understand your individual needs. Energy, focus, and motivation are interrelated but distinctly different aspects of cognitive functioning.

Energy is the capacity to do work. In a cognitive context, it refers to mental stamina and resilience. Maintaining high energy levels can help you stay alert and productive throughout the day. 

On the other hand, focus refers to the ability to concentrate on a particular task or idea without getting distracted. Motivation is the driving force that compels us to act and work towards our goals.

Different nootropics can help enhance these different aspects of cognitive functioning. Therefore, understanding your needs is the first step in choosing the best nootropics.

Best Nootropics for Energy

1. Mind Vitality – Best Nootropics for Energy Overall

Mind Vitality Nootropics bottle

Mind Vitality is one of the best supplements for motivation and energy. It is formulated with natural ingredients and designed for high-functioning adults seeking a comprehensive brain health solution.

This supplement is free from artificial substances, caffeine, and preservatives. It is designed to enhance cognitive function without depleting your energy levels. It is popular among students, working professionals, and athletes for its fast-acting blend and effectiveness.


Mind Vitality boasts a blend of 17 ingredients that have been scientifically proven to support cognition, focus, memory formation, and mental health. These ingredients are categorized into three groups:

  1. Stress Kill Switch Ingredients: Ashwagandha, Rhodiola Rosea, Korean Ginseng, and Phosphatidylserine. These ingredients are known to combat stress and boost energy levels.
  2. Brain Focus Matrix Ingredients: This group comprises Bacopa Monnieri, Ginkgo Biloba, Mucuna Pruriens, and Pine Extract. These ingredients help increase blood flow to the brain, aiding focus and mental clarity.
  3. Cognitive Accelerator Ingredients: Huperzia Serrata, L-Carnitine, and Lion’s Mane Mushroom. These ingredients help boost overall cognition.

Niacin: Niacin, or vitamin B3, is a crucial micronutrient present in animals and plants. It is involved in energy metabolism and gene expression. In Mind Vitality, Niacin supports cognitive performance and stress reduction. [2]

Ashwagandha: A renowned adaptogen, alleviates stress and induces relaxation by inhibiting cortisol-producing enzymes. It also exhibits neuroprotective properties and improves the activity of key neurotransmitters, which regulate mood and cognitive abilities.

Korean Ginseng: This perennial plant has ginsenosides that possess vasodilatory effects, enhancing blood circulation. Korean ginseng improves cognitive function and endurance through enhanced blood circulation, antioxidant defense, and neurotransmitter modulation.

Bacopa Monnieri is a wetland herb with bacosides, the active compounds that cause cognitive enhancement and stress reduction. It also improves neuroplasticity, the brain’s capacity to adapt and create novel neuron connections.

Phosphatidylserine: A brain lipid crucial for brain cell structure, function, and cognitive function, especially memory.

Huperzia Serrata: It contains Huperzine A, a potent acetylcholinesterase inhibitor. It aids in defending brain cells against oxidative stress and diminishing inflammation, which may lead to cognitive decline.

Key Benefits of Mind Vitality

Mind Vitality offers numerous health benefits:

  • Enhanced Mental Energy: Mind Vitality is one of the best nootropics for energy, helping you to remain productive throughout the day without feeling exhausted.
  • Improved Focus and Concentration: The supplements for motivation and energy boost focus and minimize procrastination by increasing mental energy, allowing you to complete tasks efficiently.
  • Enhanced Memory Power: The cognitive boosters in Mind Vitality enhance memory, mood, and information retention.
  • Reduced Stress: The supplement’s ingredients help enhance your mood and reduce stress levels, promoting well-being and improving overall mood.


Here are some of the benefits that make Mind Vitality a popular choice:

  • Uses effective, scientifically-backed natural ingredients
  • Improves brain health and enhances focus
  • Enhances mental energy without causing mental fatigue
  • Boosts memory power and retention
  • Fast and free shipping
  • Comes with a 100-day money-back guarantee


Despite its numerous benefits, Mind Vitality has a few drawbacks:

  • Only available for purchase online
  • Individual results may vary
  • Taking tablets before bed could cause sleep disturbances

Try Mind Vitality with FREE shipping and a 100-day money-back guarantee

2. NooCube – Best Nootropics for Energy That Is Caffeine-Free

NooCube, also known as NooCube Brain Productivity, is a cognitive enhancer that aims to improve mind performance, boost memory, ensure coherent communication, increase mental energy, and enhance concentration. It is one of the best nootropics for motivation, designed to break past the psychological barriers that curtail achieving life goals. 

NooCube’s natural, clinically proven ingredients blend plant extracts, amino acids, and vitamins. Some of the plant extracts in NooCube have a centuries-long history of use in traditional medicine.


NooCube’s effectiveness can be attributed to its carefully chosen ingredients. Let’s take a closer look at the key ingredients and their functions:

  • Bacopa monnieri extract: Enhances memory, reduces anxiety, and treats epilepsy.
  • Lutemax: Protects the brain from damage by free radicals, improving alertness, memory, and visual perception.
  • L-Tyrosine: Improves brain memory and reduces stress.
  • L-Theanine: Boosts the production of serotonin, improving mood and reducing anxiety.
  • Huperzia Serrata: Prevents brain cell death and oxidative stress with neuroprotective abilities.
  • Resveratrol: Anti-inflammatory compounds found in berries slow down brain aging and improve alertness.
  • Biotin: Vitamin B7 maintains the nervous system and promotes sleep and energy.
  • Pterostilbene: Anti-inflammatory compound found in berries helps prevent neurodegenerative diseases.
  • Alpha GPC: Enhances acetylcholine levels in the brain, which is crucial for learning and memory.
  • Oat straw concentrate: Regulates blood flow to the brain, beneficial for older adults with impaired brain function.
  • Cat’s Claw Concentrate: Treats Alzheimer’s, rheumatoid arthritis, and other age-related issues.

Key Benefits of NooCube

Enhanced Multitasking: In today’s busy world, multitasking has become a necessary skill. NooCube is formulated to enhance multitasking capacity without compromising the ability to concentrate on individual tasks. With these best nootropics for motivation, you can handle multiple tasks at work or juggle various responsibilities at home more efficiently.

Reduced Anxiety: Anxiety can hinder our ability to think clearly and act accordingly. NooCube fights off anxiety, providing the mental calmness required to accomplish our goals. By reducing anxiety, NooCube enables us to focus better and overcome the paralyzing effects of excessive worry.

Improved Communication: Effective communication is essential for success in various aspects of life. NooCube’s blend of ingredients improves the balance of brain chemicals, enhancing our communication abilities. 

By optimizing our brain’s ability to extract, interpret, analyze, and correlate information, NooCube promotes clearer and more coherent communication in both written and oral form.


  • 60-day money-back guarantee
  • Boosts memory
  • Supports coherent communication
  • Increases mental energy
  • Enhances concentration
  • Manufactured in an FDA-registered facility


  • Only available through the official website
  • The capsule is made from gelatin, unsuitable for vegan diets

RELATED: NooCube Review

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3. Brain Pill – Best Nootropics for Energy and Fighting Brain Fog and Anxiety

BrainPill nootropics package

Brain Pill is one of the best supplements for motivation and energy that promotes mental performance and supports brain health. Manufactured by Leading Edge Health, this supplement aims to eliminate brain fog, prevent cognitive decline, and enhance cognitive function, including focus, memory, concentration, and productivity. 


Brain Pill is formulated with natural ingredients supporting brain health and cognitive function. These ingredients can be divided into two categories: those that improve overall brain health and promote cognitive function. Let’s take a closer look at some key ingredients:

  • Cognizin (250mg): Cognizin is a natural brain booster that increases dopamine, noradrenaline, and acetylcholine neurotransmitters in the brain. It supports neuronal cell membrane performance, improves memory in older adults, enhances energy production, and promotes mental clarity. [3] 
  • Tyrosine (175mg): Tyrosine is an essential amino acid responsible for dopamine production, which improves mood and energy. It supports cognitive functions such as alertness, memory, and reasoning skills, helping clear brain fog and relieve stress. [4]
  • Phosphatidylserine (100mg): Phosphatidylserine supports healthy brain cells and improves focus. It promotes sharpness, attention, memory, language skills, and brain function. Additionally, it contains antioxidants that fight free radicals and protect against brain cell damage. [5]
  • Vitamin B12 (50mcg): Vitamin B12 is crucial for healthy brain and nerve cell function. It supports cognitive abilities, including memory, thinking, and reasoning, and synthesizes DNA and RNA neurotransmitters.
  • Vitamin B6 (6mg): Vitamin B6 plays a vital role in supporting the central nervous system and the production of dopamine and norepinephrine. It reduces stress and depression while increasing memory function.
  • Vitamin B5 (30mg): Also known as pantothenic acid, Vitamin B5 helps produce energy within brain cells. It aids in memory and controls the autonomic nervous system, supporting mental stamina, productivity, and concentration. [2]
  • Bacopa Monnieri (Synapsa) (320mg): Bacopa Monnieri enhances mental performance by improving the ability to learn new skills and tasks. It improves recall, memory, and information processing and reduces cognitive decline. [6]
  • Huperzine A (5mg): Huperzine A improves memory, alertness, learning, focus, and energy. While research is ongoing, it shows promise in enhancing brain performance and preventing the degradation of learning neurotransmitters.
  • Ginkgo Biloba (100mg): Ginkgo Biloba is an antioxidant that fights free radicals and prevents brain aging. It promotes blood circulation in the brain, improving oxygen supply and reducing forgetfulness, ultimately enhancing mental performance.

Key Benefits

  • Reduces brain fog: These best nootropics for energy help replenish brain resources and improve clarity, allowing for clearer thinking and enhanced cognitive function.
  • Improves learning skills: Brain Pill enhances thinking and processing speed, improving the ability to learn and retain knowledge.
  • Enhances memory and recall: Brain Pill supports memory function, allowing for better retention and recall of information.
  • Provides essential nutrients: Brain Pill contains vitamins and minerals that nourish the brain and support cell growth.
  • Reduces mental fatigue: Brain Pill increases the production of dopamine and serotonin, improving mood, motivation, and mental stamina, making it one of the best nootropics for motivation.
  • Improves focus: Brain Pill helps maintain focus, even in stressful environments, by reducing distractions and increasing concentration.
  • Provides neuroprotection: Brain Pill contains antioxidants that fight free radicals and oxidative stress, protecting against brain cell damage.
  • Enhances problem-solving and multitasking: Brain Pill restores brain performance, allowing for improved problem-solving abilities and multitasking skills.


  • Suitable for all ages: Brain Pill is suitable for people who want to improve their cognitive performance.
  • Natural and safe: Brain Pill contains 100% natural ingredients and is free from stimulants like caffeine. It can be used long-term without side effects or addictive effects.
  • Money-back guarantee: Brain Pill has a 67-day guarantee, allowing users to try the product risk-free.
  • Made in the USA: Brain Pill is manufactured in the USA, ensuring quality and adherence to regulatory standards.
  • No prescription required: Brain Pill does not require a prescription, making it easily accessible for individuals seeking cognitive enhancement.
  • Suited for both men and women: Brain Pill is suitable for both genders, catering to a wide range of users.


  • Limited availability: Brain Pill is only available on the official website, limiting accessibility.
  • Varied results: The effectiveness of the Brain Pill may vary from person to person due to individual differences and factors.

RELATED: Brain Pill Review

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4. FOCL Day – Best Nootropics for Motivation and Natural Energy

FOCLDay Nootropics

FOCL Day is a specially formulated nootropic supplement to supercharge your day with natural energy. This unique product combines the wellness benefits of CBD with a blend of adaptogens and botanicals, making it one of the best nootropics for energy.

These supplements for motivation and energy are vegan-friendly, GMO-free, and cruelty-free, aligning with FOCL’s commitment to natural and ethical products. FOCL Day is also THC-free, ensuring you reap the benefits of CBD without any psychoactive effects.


FOCL Day is packed with a powerful blend of ingredients handpicked for their potential to enhance energy, focus, and improve cognitive function. Here’s a rundown of what each capsule of the best nootropics for energy brings:

  • Organic Lion’s Mane: Known as the “King” of medicinal mushrooms, Lion’s Mane supports cognitive performance and helps beat brain fog.
  • Organic Rhodiola Rosea: This natural adaptogen fights fatigue and supports mental alertness and concentration.
  • L-theanine: This amino acid in green tea helps improve concentration, memory, and focus.
  • Vitamin B6: An essential nutrient for brain health, Vitamin B6 assists in mood regulation and enhances memory.
  • Organic Bacopa Monnieri: Known as Brahmi in traditional Ayurvedic medicine, Bacopa Monnieri supports improved concentration and attention while providing antioxidant benefits.
  • Premium Hemp CBD: The core ingredient of FOCL Day, CBD helps the mind and body stay focused and relaxed.


  • All-natural, vegan-friendly, and non-GMO ingredients.
  • Owned and operated by FOCL, ensuring superior quality control.
  • Subscription plans are available for added convenience and savings.
  • A 60-day satisfaction guarantee for a risk-free purchase.
  • Free shipping on all orders.


  • Limited product range compared to other CBD brands.
  • Some users may not enjoy the natural flavor of the supplement.

Get FOCL Day with FREE shipping and a 60-day money-back guarantee

5. Elm & Rye – Best Nootropics for Energy and Mental Focus

Elm & Rye Nootropics

Elms & Rye supplements for motivation and energy are formulated with natural ingredients. These brain supplements are carefully crafted to boost sustainable energy without the crashes and jitters associated with other energy products.


Elms & Rye Supplements for motivation and energy are made with all-natural ingredients carefully selected for their energy-boosting properties. These ingredients include:

  • Caffeine: Derived from natural sources like green tea, caffeine is a stimulant to increase alertness and focus.
  • Ginseng: Known for its adaptogenic properties, ginseng helps the body cope with stress and improves mental performance.
  • B Vitamins: Essential for energy metabolism, B vitamins play a crucial role in converting food into energy.
  • L-Theanine: L-theanine is found in tea leaves and promotes relaxation and mental clarity without causing drowsiness.


  • Natural and Clean Ingredients: Elms & Rye is made with premium, natural ingredients, ensuring you’re fueling your body with only the best.
  • Sustained Energy: With Elms & Rye’s best nootropics for energy, you can enjoy sustained energy throughout the day without experiencing crashes or jitters.
  • Improved Focus and Mental Clarity: The blend of adaptogens and vitamins in Elms & Rye supports cognitive function, helping you stay focused and sharp.
  • Convenient Capsule Form: Elms & Rye is easy to incorporate into your daily routine, thanks to its convenient capsule form.


  • Limited Availability: Elms & Rye’s best nootropics for energy may not be widely available in all regions, so that accessibility could be a potential limitation for some individuals.
  • Individual Results May Vary: The effectiveness of Elms & Rye may vary from person to person. Factors like metabolism and overall health can influence how quickly you notice the desired effects.

Get started with Elm & Rye

6. BetterBrand – Best Nootropics for Energy for Various Dietary Needs

BetterBrand Nootropics

BetterBrand is a reputable company that produces high-quality supplements for motivation and energy. Their commitment to quality is evident in their products, which are made in the United States and undergo rigorous lab testing. 

BetterBrand supplements for motivation and energy are gluten-free, kosher, and vegetarian, making them suitable for various dietary needs.


BetterBrand’s best nootropics for energy contain a unique blend of ingredients that synergize to provide an effective energy boost. Here are some key ingredients in this supplement:

  • Caffeine: Caffeine is a well-known stimulant that can increase alertness and concentration. It acts as a central nervous system stimulant, promoting wakefulness and reducing fatigue. [7]
  • L-Theanine: L-Theanine is an amino acid that is commonly found in tea leaves. It has been shown to promote relaxation without causing drowsiness, making it an ideal complement to caffeine.
  • Methylliberine: Methylliberine is a naturally occurring compound found in tea leaves. It has been shown to improve alertness and focus, making it a valuable addition to an energy supplement.
  • Rhodiola: Rhodiola is an adaptogenic herb used for centuries to combat fatigue and increase energy levels. It can also help improve mental performance and reduce stress.
  • Vitamin B Complex: The B vitamins, including B6, B12, and folic acid, play a crucial role in energy production and metabolism. They help convert food into energy, which is essential for maintaining optimal energy levels.

Key Benefits

  • Improved Cognitive Function: BetterBrand aims to improve cognitive function, including memory, focus, and mental clarity. Key ingredients in these supplements for motivation and energy have demonstrated cognitive-enhancing effects in various studies, such as Bacopa Monnieri. [7]
  • Enhanced Joint Health: BetterBrand’s Joint Supplement supports joint health and mobility. The primary ingredients have shown potential in reducing joint pain and enhancing mobility in various studies, such as glucosamine. [8]
  • Improved Sleep Quality: BetterBrand’s Sleep Supplement aims to enhance sleep quality and duration. Key ingredients have shown promising results in improving sleep in various studies, like melatonin. [9]
  • Increased Energy and Endurance: BetterBrand’s Energy Supplement boosts energy and endurance. The key ingredients have shown potential in improving energy and endurance in various studies, like caffeine. [10]
  • Improved Digestive Health: BetterBrand’s Probiotic Supplement promotes digestive health and a healthy gut microbiome. The primary ingredients have shown promising results in improving digestive health in various studies, like Lactobacillus Acidophilus.[11]


  • Natural ingredients: BetterBrand’s Energy Supplement is formulated with natural ingredients, providing a safer alternative to synthetic energy boosters.
  • Increased energy and endurance: This supplement is designed to enhance energy levels and improve endurance, allowing you to perform at your best throughout the day.
  • Scientifically backed: BetterBrand’s Energy Supplement is backed by scientific research, ensuring you get an effective and safe product.
  • Quality assurance: All BetterBrand products undergo lab testing to ensure purity, potency, and quality.


  • Individual results may vary: While many customers have reported positive experiences with BetterBrand’s Energy Supplement, individual results may vary.
  • Price: Some customers may find the price of BetterBrand’s Energy Supplement higher than other supplements for motivation and energy on the market.

Get started with BetterBrand

7. Performance Lab Mind – Best Nootropics for Energy and Boosted Cognitive Performance

Performance Lab Mind Nootropics package

Performance Lab is a UK-based supplement company that manufactures its products in the USA. Known for its cutting-edge supplement system, Performance Lab has carved a niche in the market with their dedication to improving cognitive performance and overall health. 

The centerpiece of their product line is Performance Lab Mind, one of the best nootropics for motivation and energy. These supplements for motivation and energy have been designed to harness the power of various natural ingredients to boost cognitive performance, helping individuals perform better in their day-to-day activities.


Performance Lab Mind supplements for motivation and energy contain a blend of scientifically-backed ingredients:

  • Citicoline (Cognizin®): This naturally occurring choline source is present in every cell in your body. It is vital for synthesizing acetylcholine, a primary neurotransmitter in signaling between neurons for cognition, learning, memory, and recall.
  • Phosphatidylserine (Sharp-PS® Green): This fatty substance protects the cells in the brain and helps transmit messages between them, enhancing brain performance and protecting it from aging.
  • Ajipure® L-Tyrosine: This amino acid is a ‘building block’ for protein and is closely connected to dopamine, which is vital to the brain.
  • Maritime Pine Bark Extract: With a rich mixture of antioxidants, Maritime Pine Bark can aid blood flow, prevent infections, reduce swelling, and boost brain health.

Key Features

  • Full Ingredient Disclosure: Unlike many other supplements for motivation and energy, Performance Lab fully discloses the amount of each ingredient in its products. This transparency allows consumers to understand exactly what they are ingesting.
  • High-Quality Ingredients: The company uses branded ingredients like Ajipure® L-Tyrosine, Cognizin®, and Sharp PS® Green in its supplements for motivation and energy, ensuring their potency and purity.
  • No Artificial Fillers: Performance Lab Mind is devoid of artificial fillers. Every capsule is packed with 100% nourishment.
  • Compliance with Stringent Standards: Performance Lab is NSF cGMP compliant certified, certified by the Natural Products Association (NPA), approved by Underwriter Laboratories (UL), and meets other stringent standards across the United States and the United Kingdom.
  • Vegan-Friendly: The capsules used in Performance Lab Mind are made from fermented tapioca, making them vegan-friendly and more easily absorbed.
  • Money-Back Guarantee: The company offers a 30-day, 100% money-back guarantee on all its products.


  • Full ingredient disclosure
  • High-quality, branded ingredients
  • No artificial fillers
  • Vegan-friendly capsules
  • Compliance with stringent standards
  • 30-day money-back guarantee


  • Only available on the official website
  • It might be expensive for some users

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8. Mind Lab Pro – Best Nootropics for Energy and Productivity

MindLabPro Nootropics

Mind Lab Pro is a cognitive enhancing supplement, or nootropic, designed to boost brain function on multiple levels. This is one of the best nootropics for energy, and it comprises eleven natural ingredients, each clinically proven to improve cognitive function over the short, medium, and long term.


Mind Lab Pro’s unique blend of natural ingredients is attributed to its effectiveness. Let’s take a closer look at the key ingredients:

  • Citicoline: A vital ingredient in Mind Lab Pro that increases levels of acetylcholine, a neurotransmitter crucial for learning and memory. By boosting acetylcholine, citicoline enhances cognitive function and mental performance.
  • Bacopa Monnieri: Another key ingredient contains bacosides, which promote neurogenesis and regulate neurotransmitter activity. This leads to improved memory, focus, concentration, and alertness.
  • Lion’s Mane Mushroom: Organic lion’s mane mushroom is rich in compounds that enhance mental clarity and cognitive function. It acts as an antioxidant, increases nervous system activity, and has been associated with improved memory, stress relief, and better sleep quality.
  • Phosphatidylserine: A phospholipid crucial in maintaining healthy brain cell membranes. It supports cognitive function, memory, and overall brain health.
  • L-Theanine: An amino acid that promotes relaxation and reduces stress and anxiety. It enhances mood balance and helps improve mental clarity and focus.
  • Rhodiola Rosea: An adaptogenic herb that helps the body adapt to stress and promotes cognitive function. It enhances energy levels, mental performance, and mood.
  • Maritime Pine Bark Extract: Maritime pine bark extract contains powerful antioxidants that protect brain cells from damage caused by free radicals. It supports overall brain health and improves focus and concentration.
  • Vitamins B6, B9, and B12: Essential for maintaining optimal brain health and cognitive function. They are crucial in nerve cell health, neurotransmitter production, and brain communication.

Key Features 

  • Provides short, medium, and long-term benefits for cognitive health.
  • Enhances neural plasticity and neural structure.
  • Sharpens focus and attention span.
  • Formulated with eleven natural, clinically-proven ingredients.
  • Improves calmness, focus, self-drive, multi-tasking ability, reaction speed, memory retention, and idea clarity.
  • Crafted by a reputable and reliable manufacturer, Opti-Nutra.


  • Increases focus, attention, and mental clarity
  • Enhances memory retention and recall
  • Supports long-term brain health and slows down aging
  • Made from 100% natural ingredients
  • Manufactured by a reputable company in GMP-compliant and FDA-registered facilities
  • Positive customer reviews and endorsements from health experts
  • Comes with a 90-day money-back guarantee
  • Free worldwide shipping


  • Not recommended for pregnant or nursing females
  • Available for purchase only from the official website
  • Availability may be limited in certain regions

Try Mind Lab Pro with a 30-day RISK-FREE trial

9. ONNIT Alpha Brain – Best Nootropics for Motivation and Improved Memory

ONNIT Alpha Brain nootropics

Alpha Brain, a product of Onnit Labs, is a well-known brand in the nootropic industry. It primarily comprises three proprietary Onnit blends that aim to augment alpha brain wave activity and regulate neurotransmitter production. It pledges improvements in thought processing speed, memory, focus, and overall cognitive function.


The efficacy of any supplement largely depends on its ingredients. Alpha Brain comprises three key blends:

  • Onnit Flow Blend: This blend, totaling 650mg, contains L-Tyrosine, Oat Straw Extract, and Phosphatidylserine. It aims to activate the flow state, a mental state with heightened focus.
  • Onnit Focus Blend: Comprising 240mg of Alpha GPC, bacopa, and toothed club moss extract, this blend is designed to produce caffeine-like effects but without the associated crash or jitters.
  • Onnit Fuel Blend: A 60mg blend of L-Leucine and Pterostilbene aims to provide a jitter-free increase in energy levels.

Key Features

Alpha Brain’s best nootropics for energy boast several features that make it an appealing choice for those seeking cognitive enhancement:

  • Clear Mental State: Alpha Brain aims to foster an environment conducive to optimal brain activity, promoting lasting mental clarity.
  • Improved Thought Processing: The supplement is formulated to aid mental processing, boosting cognitive efficiency.
  • Enhanced Focus and Memory: Alpha Brain is also designed to support focus and memory, which can be especially beneficial for tasks that require attention to detail.
  • Caffeine and Gluten-Free: For those with dietary restrictions or sensitivities, it’s worth noting that Alpha Brain is both caffeine and gluten-free.


  • Enhances thought processing speed and multitasking ability.
  • Improves memory recall ability.
  • Sharpens focus and boosts cognitive attention and concentration.
  • Supports emotional well-being and mood.
  • Backed by Unilever, a leading global consumer goods company.


  • The quantity of vitamin B6 per daily serving exceeds the FDA’s recommended daily values. [12]
  • Contains proprietary blends, which can mask the actual quantities of each ingredient.

Get started with ONNIT Alpha Brain

Understanding the Mechanisms of Natural Nootropics

To appreciate the benefits of natural nootropics fully, it is crucial to understand the mechanisms through which they exert their effects. Several pathways and systems in the brain are responsible for cognitive function, and natural nootropics target these pathways to enhance mental performance. [13]

Glutaminergic Signaling: The Key to Cognitive Enhancement

Glutamate is a neurotransmitter that plays a crucial role in cognitive processes such as learning and memory. Natural nootropics have been shown to modulate glutaminergic signaling, leading to improved synaptic transmission and enhanced cognitive function. 

The release of glutamate activates receptors such as N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), which are responsible for synaptic plasticity and memory formation. By modulating these receptors, natural nootropics can enhance synaptic transmission and improve cognitive performance. [14]

Cholinergic System: Boosting Memory and Attention

The cholinergic system is another important target for natural nootropics. Acetylcholine is a neurotransmitter that plays a key role in memory and attention. Dysfunction of the cholinergic system is observed in conditions such as Alzheimer’s, leading to cognitive impairment. 

Natural nootropics have been shown to enhance the release of acetylcholine and upregulate cholinergic receptors, improving memory and attention. [15]

Amyloid Precursor Protein: Implications for Memory Formation

Amyloid precursor protein (APP) is a cellular component involved in memory formation. Natural nootropics have been shown to modulate the processing of APP, leading to the formation of specific neurotrophic APP fragments that are important for memory function. 

By promoting the expression of APP and preventing the formation of amyloid-beta plaques, natural nootropics can protect against memory impairment. [16]

Secondary Messengers: Signaling Pathways for Cognitive Enhancement

Secondary messengers, such as protein kinase C (PKC), play a crucial role in mediating the effects of natural nootropics on cognitive function. Activation of PKC has been shown to enhance synaptic plasticity and improve memory performance. 

Natural nootropics can enhance cognitive function and improve synaptic transmission by modulating the activity of PKC and other secondary messengers. [13]

Promising Natural Nootropics and Their Cognitive Benefits

Now that we understand how natural nootropics exert their effects let’s explore some of the most promising compounds and their cognitive benefits.

Bacopa monnieri: Enhancing Memory and Cognitive Function

Bacopa monnieri, also known as Brahmi, is a natural nootropic derived from the family of Scrophulariaceae. It has been used for centuries in Ayurvedic medicine to enhance memory and intellect. Bacopa monnieri contains compounds called bacosides, which have been shown to improve memory and cognitive function. 

These compounds enhance protein kinase activity and promote protein synthesis in the hippocampus, improving memory performance. Bacopa monnieri also exhibits antioxidant and DNA-protective properties, making it a promising natural nootropic for cognitive enhancement.

Ginkgo biloba: Protecting the Brain and Enhancing Memory

Ginkgo biloba, also known as the maidenhair tree, is a natural nootropic derived from the family of Ginkgoaceae. It is often called a “living fossil” for millions of years due to its unchanged morphology. Ginkgo biloba has been extensively studied for its neuroprotective effects and its potential to improve memory and cognitive function. 

The plant contains compounds called ginkgolides, which have been shown to inhibit amyloid-beta aggregation and protect against oxidative damage. By reducing apoptosis and inhibiting caspase-3 activation, Ginkgo biloba can protect the brain from age-related cognitive decline and improve memory function, making it one of the best nootropics for motivation.

Panax ginseng: Boosting Cognitive Performance and Memory

Panax ginseng, also known as Asian ginseng, is often called the “king herb” in traditional Chinese medicine and one of the best nootropics for energy. It has been used for centuries to enhance cognitive performance and memory. 

Panax ginseng contains active compounds called ginsenosides, which have been shown to increase the release of neurotransmitters in the brain and improve memory and cognitive function. 

These compounds also exhibit antioxidant properties and have been found to suppress Alzheimer’s disease-like pathology. Panax ginseng is a promising natural nootropic for enhancing cognitive performance and protecting against cognitive decline.

Rhodiola rosea: Enhancing Cognitive Function and Reducing Stress

Rhodiola rosea, also known as golden root or Arctic root, is a natural nootropic that has been used for centuries to enhance cognitive function and reduce stress. It is classified as an “adaptogen” and is known for its ability to increase endurance, resistance, and resilience to stressful situations. 

Rhodiola rosea has been shown to increase the levels of serotonin and norepinephrine in the brain, leading to improved cognitive function and enhanced memory and learning. It also exhibits neuroprotective and antioxidant effects, making it a promising natural nootropic for cognitive enhancement.

What Are the Best Nootropics for Energy?

One of the primary reasons people turn to the best nootropics for energy levels is the increasingly demanding lifestyles often result in mental fatigue and a lack of energy. Fortunately, several nootropics can help combat this.

One of the best nootropics for energy is Rhodiola Rosea. Known as an adaptogen, it helps the body adapt to stress and combat fatigue. Another powerful, best nootropics for energy is Panax Ginseng, used in traditional medicine for centuries to increase energy and reduce fatigue.

Another popular nootropic for energy is Modafinil. Originally developed to treat sleep disorders, Modafinil has become a favorite among those seeking an energy boost. It promotes wakefulness and can significantly improve performance on lengthy tasks.

Best Nootropics for Motivation: A Closer Look

Motivation is crucial to success. Maintaining high motivation levels can often be challenging in our professional or personal lives. Thankfully, certain of the best nootropics for motivation are known for their ability to boost overall cognitive function.

Phenylpiracetam is often considered one of the best nootropics for motivation. It stimulates the dopaminergic system, directly linked to motivation and reward. Another nootropic that positively impacts motivation is Mucuna Pruriens. It contains L-DOPA, a precursor to dopamine, thus boosting levels of the ‘feel-good’ neurotransmitter in the brain.

Another of the best nootropics for motivation is Noopept. Known for its neuroprotective properties, Noopept also enhances brain-derived neurotrophic factor (BDNF) levels, which play a vital role in motivation.

Exploring the Best Nootropic for Focus

In our increasingly distracting world, maintaining focus can be challenging. Concentrating on your work is crucial whether you’re a student, a professional, or an artist. Certain nootropics are known for their ability to enhance focus and concentration.

Piracetam, one of the oldest and most researched nootropics, is known to improve focus. It does this by enhancing the function of acetylcholine, a neurotransmitter involved in learning and memory.

Another best nootropic for focus is Aniracetam. It has anxiolytic properties, which can help reduce anxiety and improve focus. Additionally, it stimulates the release of dopamine and serotonin, which play a crucial role in maintaining focus.

Motivation Supplements: How Do They Work?

The best nootropics for motivation influence the levels and functioning of various neurotransmitters associated with motivation and reward, such as dopamine, serotonin, and norepinephrine.

For example, L-Tyrosine, a common ingredient in motivation supplements, is a precursor to dopamine, norepinephrine, and adrenaline. By increasing the availability of these neurotransmitters, L-Tyrosine can help improve motivation.

Similarly, Phenylalanine, another common ingredient in the best nootropics for motivation, is converted into L-Tyrosine in the body, boosting dopamine levels and increasing motivation.

Energy and Focus Pills: A Comprehensive Guide

Energy and focus pills, like motivation supplements, often blend several nootropics designed to boost energy levels and improve focus. They target various aspects of brain function, such as neurotransmitter levels, brain wave activity, and brain cell health.

For instance, Caffeine and L-Theanine, a common pair in the energy and focus pills, work together to boost energy levels and improve focus. While caffeine stimulates the nervous system to increase alertness and energy, L-Theanine promotes relaxation and counteracts the jittery effects of caffeine, resulting in a calm, focused state of mind.

Best Nootropics for ADHD

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity symptoms. While standard pharmaceutical treatments have been effective for many individuals with ADHD, some patients experience limited success or adverse side effects. 

As a result, there has been growing interest in exploring alternative and complementary treatments, such as nootropics, to manage ADHD symptoms.

Nootropics offer a potential avenue for individuals with ADHD seeking alternative or complementary treatments. While research on the efficacy and safety of specific nootropics for ADHD is still evolving, certain substances such as omega-3 fatty acids, Bacopa monnieri, ginseng, Rhodiola rosea, and ginkgo biloba have shown promise in improving cognitive function and alleviating ADHD symptoms. 

It is important to approach nootropics cautiously, consulting with a healthcare professional and considering individual factors before integrating them into an ADHD treatment plan. With careful consideration and guidance, nootropics may serve as valuable tools in the management of ADHD symptoms and the optimization of cognitive function. [17]

The Science Behind Nootropics for ADHD

The use of nootropics in ADHD treatment is based on the premise that certain substances can improve neurotransmitter function, enhance brain activity, and alleviate ADHD symptoms. 

While the exact mechanisms of action may vary depending on the specific nootropic, many of these substances target neurotransmitters such as dopamine, norepinephrine, and serotonin, which are involved in attention, impulse control, and mood regulation.

Best Nootropics for Anxiety: An Overview

While nootropics are primarily known for their cognitive-enhancing properties, certain nootropics can also help manage anxiety. Anxiety can severely impact cognitive function, affecting focus, memory, and mental clarity.

Ashwagandha is one of the best nootropics for energy and anxiety, an adaptogenic herb known for reducing stress and anxiety. Another nootropic that can help manage anxiety is L-Theanine. It promotes relaxation without sedation, effectively reducing stress and anxiety.

RELATED: Best nootropics for anxiety

Building the Best Nootropics Stack for Your Needs

Building the best nootropics stack involves a combination of different nootropics to achieve desired cognitive enhancements. The ‘stacking’ of nootropics can result in a synergistic effect where the benefits of individual nootropics are amplified.

However, building the best nootropics for energy stack is a highly individual process. It depends on your specific cognitive needs, whether improving focus, boosting energy, enhancing memory, or increasing motivation. It also requires a good understanding of how different nootropics work and interact with each other.

Best Nootropics for Energy: FAQ

This section answers some frequently asked questions about the best nootropics for energy.

Are the Best Nootropics for Energy Safe?

Most nootropics are considered safe when used as directed. However, like any supplements for motivation and energy, they can have side effects, especially when taken in high doses or combined with other substances. Therefore, starting with a low dose and monitoring your body’s response is always recommended.

Can the Best Nootropics for Energy Also Help With Depression?

Certain of the best nootropics for energy have mood-enhancing properties and can help manage symptoms of depression. However, they should not be used as a substitute for professional medical advice and treatment.

Can I Take the Best Nootropics for Energy With Other Medications?

The interaction of nootropics with other medications depends on the specific nootropic and medication in question. Therefore, it’s recommended to consult with a healthcare professional before taking the best nootropics for energy if you’re on other medications.

Conclusion: What Are the Best Nootropics for Energy?

Nootropic supplements offer a promising solution to boost energy, improve focus, and enhance motivation. Whether you’re looking for the best nootropics for energy, the best nootropics for motivation, or the best nootropic for focus, there’s likely a nootropic out there that can meet your needs.

Some of the best nootropics for energy include Mind Vitality, NooCube, Brain Pill, and FOCL Day. However, it’s crucial to remember that nootropics are not a magic solution. They should be used with a healthy lifestyle, including a balanced diet, regular exercise, and adequate sleep.

As always, before starting any new supplements for motivation and energy, consulting with a healthcare professional is recommended. This is particularly important if you have any underlying health conditions or are taking other medications.

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